Name of the project:
Financial support: State budget Ministery of Education, Research and Youth Programm: Partnership in Priority Fields
Project value: 1.842.000 lei, financial source - state budget exclusively
Project duration: 36 month (3 years)
Project sustention: Obesity is a world major health problem with important social and economical effects. It has a direct impact on the cardiovascular system. Physiopathology of obesity is complex and the investigation of obese patients is difficult because of their specific morphology and technical limitations of apparatuses, usually designed to perform till 100 kg. Our project is taking into account the integration of some complex evaluations modalities of obesity cardiac affection; including beside echocardiography, cardio- scintigraphy - the golden standard to determine ejection fraction of both ventricles, the right ventricle being difficult to determine by other noninvasive means, because of its specific morphology.
The main goal is to elucidate the obesity cardiovascular affection mechanisms using mathematical model, an objective and precise method of different investigation data integration.
We propose to contribute to more defining the actual nosological content of obesity cardiomyopathy, whose pathogenic mechanism due to lipid infiltration, apoptosis and some specific genes activation would necessitate cardiac biopsy - invasive method difficult to use - to confirm the diagnosis. The cardiomyopathy also comprises the alteration of myocardial contraction, impossible to be determined by non-invasive methods. On contrary, mathematic model can be used to estimate, noninvasively, myocardial contractility with practical and theoretical implications. The results of this project will consist in an integral model, for a better understanding of complex hemodynamic mechanisms implicated in obesity physiopathology, on rest and effort. Also the patients will be followed up and the factors with predictive value for cardiovascular events evolution will be identified.
The research personnel:
01/02/2008 Beginning of obese subjects inclusion in the study
Some of the main
results obtained so far in our study are:
We also presented and published numerous works at International Congresses of Cardiology, Echocardiography and Bioengineering, such as:
Colentina Clinic Hospital, Bucharest, Code 020125, tel: +4 021 317.32.45, fax: +4 021 316.55.12, e-mail: email@example.com, registred at Comerce Registry nr 932/11.07.1973, fiscal code 4283929, bank account IBAN: RO74TREZ7025041XXX000303, Trezoreria sector 2 Bucharest, reprezented by DIRECTOR Dr. Andreescu Bogdan, FINNANCIAL DIRECTOR Dinescu Maria, PROJECT DIRECTOR Prof. Dr. Gheorghe Andrei Dan and PROJECT MANAGER Dr. Stanescu Cristina Maria, tel. +4 0745.072.679, Fax: +4 021 316.55.12, email: firstname.lastname@example.org.
Fundeni Clinical Institute, Bucharest, Code 022328, tel: +4 021 318.04.00, fax: +4 021 318.04.44, e-mail: email@example.com, registred at Comerce Registry nr. 873/1959, fiscal code 4204003, bank account IBAN: RO69TREZ702504XXX000296, Trezoreria sector 2, reprezented by DIRECTOR Dr. Popa Constantin Nicolae, FINNANCIAL DIRECTOR Diaconu Claudia, PROJECT MANAGER Dr. Stanescu Dan Adrian, tel. +4 0745.079.750, Fax: +4 021 318.04.44, email: firstname.lastname@example.org.
University Politehnica of Bucharest, Bucharest, Code 060042, tel: +4 021 402.94.61, fax: +4 021 318.10.01, e-mail: email@example.com, registred at Comerce Registry nr. 175/3.08.1948, fiscal code 4183199 , bank account IBAN: RO09TREZ7065003XXX000021 , Trezoreria sector 6, reprezented by RECTOR Prof, Dr. Ing. Andronescu Ecaterina, FINNANCIAL DIRECTOR ECEE Center Ticu Ecaterina, PROJECT MANAGER Assoc. Prof. Dr. Ing. Manoliu Vasile, tel. +4 021 402.96.54, Fax: +4 021 402.91.71 , email: firstname.lastname@example.org.